Nourishing the Skin with Injectables: Profhilo vs Skin Boosters vs Rejuran

How do we go about choosing the right injectable for nourishing our facial skin, one might ask? Should we choose the latest popular Profhilo injectable, the classic hyaluronic acid skin boosters or the healing Rejuran injectable? Actually, the answer can be more than one.

  1. Profhilo® injectable 逆時針
Vale Medical Aesthetics | Profhilo time reversing injectable
Profhilo – Injectable Moisturizer

Profhilo, founded in Italy, is the first revolutionary bio-remodelling injectable skincare that addresses skin laxity and signs of aging through the bio-stimulation of collagen, elastin and adipocytes (fats) stem cells that were lost through skin aging.

It contains 100% pure hyaluronic acid and is formulated with the unique patented NAHYCO® Hybrid Technology. Using the 5 BAP (Bio Aesthetic Points) injection technique per side of the face, Profhilo diffuses through the different skin layers, across the widest sections of the face through, bringing a natural and lasting refreshed look.

Injectables | Profhilo Injection Technique | Bioremodeling | IBSA
BAP points

Profhilo provides firming, tightening and lifting effect to the skin plus improves overall skin quality and hydration. It helps provide tissue repair and is useful for improving acne scarring as well.

2. Skin Boosters injectable 水光针

Skin Booster | Juvederm Volite | Restylane
Skin Booster Brands

Our clinic carries skin boosters from U.S.A such as Juvederm Volite and Restylane Vital Light Skin Boosters. Skin boosters containing hyaluronic acid are injected into the skin using an injector device or via manual injections and act like water reservoirs under the skin because hyaluronic acid can hold up to 1000x of its molecular weight in water.

Skin boosters can help to combat the effects of aging with increased skin hydration, skin radiance, skin elasticity and skin texture.

3. Rejuran injectable 婴儿针

Rejuran Healer Treatment  | Vale Medical Aesthetics
Rejuran Healer

Rejuran Skin Healer injection (the most commonly used Rejuran injection), founded in South Korea, is a rejuvenating skin treatment made of biological molecules called polydeoxyribonucleotides (PDRN). Nucleotides are the basic structural units which make up DNA. The DNA extract in Rejuran Healer is obtained from salmon, which is then fragmented into PDRNs. It does not contain any hyaluronic acid.

Rejuran Healer mainly works through wound healing with stimulation of growth factors and increased microcirculation. It also has anti-inflammatory effects through scavenging of free radicals and blocks inflammatory cytokines in the skin. However, it is not meant for hydration of the skin.

Patients who have acne scars, open pores, sensitive skin, pigmentation, uneven skin tone/texture as well as redness stand to benefit from Rejuran injections. 

Comparison table between the 3 injectables

 ProfhiloJuvederm VoliteRestylane SkinboostersRejuran Skin Healer
CompositionNon-crosslinked HACross-linked HA with lidocaineCross-linked HA with lidocainePDRN
Hyaluronic acid concentration (mg/ml)32mg/ml12mg/ml20mg/mlNil
Number of injection points5 points on each side of the faceMultiple injections up to 100 points for whole faceMultiple injections up to 100 points for whole faceMultiple injections up to 100 points for whole face
Promotes hydrationYesYesYesNo
Stimulates elastin and adipocytes stem cells for firming and liftingYesNoNoNo
Improves skin textureYesYesYesYes
Healing for skin and acne scars+NoNo++
Price per treatment+++++++
Treatment regime2 treatments at 1 month interval; maintenance thereafter: every 9-12 months1 treatment only, maintenance: every 9 months3 treatments at 1 month interval; maintenance thereafter: every 6-9 months3 treatments at 1 month interval; maintenance thereafter: every 9-12 months
Comparison Table

HA: Hyaluronic acid

PDRN: polydeoxyribonucleotide

Which injectable is suitable for me?

Profhilo is highly recommended as it has the highest concentration of HA per ml of injectable, able to achieve all indications of treatment and needs the fewest injection points. However, it has the highest cost. So, for patients whom want the maximal effect with minimum injection points and are comfortable with the cost, they can go for the Profhilo Injectable.

For patients whom solely want hydration for the skin at lower cost but is able to tolerate more injection points, they can consider Juvederm Volite or Restylane Skinboosters.

As for patients whom have more issues with skin texture/ acne scars and also want hydration, you can have two different injectables! Profhilo injectable can be combined with Rejuran Skin Healer injectable. As Rejuran Skin Healer is not recommended to be injected within a year of cross-linked HA, Profhilo is the safest for combination with Rejuran injectable as it does not contain any cross-linked HA.

Schedule an appointment with us so we can advise you on the best treatment regime for nourishing your skin!

Disclaimer: The material contained in this article is for informational purposes only and do not constitute medical advice. The content is not intended to be a substitute for doctor’s advice, diagnosis, or treatment.

<strong>Dr Cheak Wan Ying</strong>
Dr Cheak Wan Ying

Ministry of Health Accredited Doctor

Bachelor of Medicine, Bachelor of Surgery (MBBS, NUS)
Master of Medicine in Family Medicine (NUS)

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